Methods for inhibiting smooth muscle cell proliferation and...

A - Human Necessities – 61 – K

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Details

A61K 31/4535 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/445 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2118095

ABSTRACT Methods of inhibiting smooth muscle cell proliferation and restinosis comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula Image (I) or Image (II) wherein R1 and R3 are independently hydrogen, -CH3, Image , or Image , wherein Ar is optionally substituted phenyl; R2 is Image , Image , or Image and R4 is hydrogen or -OR1, and pharmaceutically acceptable salts and solvates thereof. Also provided is a method for inhibiting restinosis.

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