C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2332121
This invention provides <i>in vivo</i> or <i>in vitro</i> methods for screening for inhibitors of TEF-3 activity. The invention further provides methods for identifying TEF-3 interacting factors. The invention still further provides methods for treating matrix metalloprotease-mediated diseases, including those of the musculoskeletal system, and cardiac muscle, as well as growth related skeletal diseases.
L'invention concerne des procédés <i>in vivo</i> ou <i>in vitro</i> de sélection d'inhibiteurs d'activité TEF-3. L'invention concerne en outre des procédés permettant d'identifier des facteurs d'interaction de TEF-3. Enfin, l'invention concerne des procédés pour le traitement d'affections à médiation métalloprotéase matricielle, y compris celles du système musculo-squelettique, et du muscle cardiaque, ainsi que de maladies squelettiques liées à la croissance.
Tindal Michael Howard
Wang Richard Liqun
Kirby Eades Gale Baker
The Procter & Gamble Company
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