Methods for inhibiting vascular hyperpermeability

Details Methods for inhibiting vascular hyperpermeability Methods for inhibiting vascular hyperpermeability

A - Human Necessities

61

K

A61K 38/00 (2006.01)

Patent

CA 2480809

The present invention relates to methods for decreasing or inhibiting disorders associated with vascular hyperpermeability and to methods of screening for compounds that affect permeability, angiogenesis and stabilize tight junctions. In one aspect of the present invention there is provided a method of decreasing or inhibiting vascular hyperpermeability in an individual in need of such treatment. The method includes administering to the individual an effective amount of an antiangiogenic compound selected from the group consisting of endostatin, thrombospondin, angiostatin, tumstatin, arrestin, recombinant EPO and polymer conjugated TNP-470. Other antiangiogenic compounds are disclosed herein.

L'invention concerne des méthodes permettant de réduire ou d'inhiber des troubles associés à l'hyperperméabilité vasculaire et des méthodes permettant de cribler des composés qui affectent la perméabilité et l'angiogénèse et stabilisent des jonctions étroites. Dans un aspect, l'invention concerne une méthode permettant de réduire ou d'inhiber l'hyperperméabilité chez un individu ayant besoin de ce traitement. Ladite méthode consiste à administrer à cet individu une quantité efficace d'un composé antiangiogène sélectionné dans le groupe constitué par l'endostatine, la thrombospondine, l'angiostatine, la tumstatine, l'arrestine, l'EPO de recombinaison et TNP-470 conjugué avec un polymère. L'invention concerne également d'autres composés antiangiogènes.

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