A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/4535 (2006.01) A61K 31/55 (2006.01)
Patent
CA 2222292
Methods of inhibiting vascular smooth muscle cell migration comprising administering to a human or other mammal in need of treatment an effective amount of a compound having formula (I) wherein R1 and R3 are independently hydrogen, -CH3, (a), or (b), wherein Ar is optionally substituted phenyl; R2 is pyrrolidino, hexamethyleneimino, or piperidino; and pharmaceutically acceptable salts and solvates thereof.
L'invention concerne des procédés destinés à inhiber la migration de cellules de muscles lisses vasculaires, consistant à administrer à un être humain ou à d'autres mammifères nécessitant un traitement, une quantité efficace d'un composé de formule (I) ou de ses sels et solvates pharmaceutiquement acceptables. Dans la formule (I), R?1¿ et R?3¿ représentent indépendamment l'un de l'autre hydrogène, -CH¿3?, (a), ou (b), Ar représentant phényle éventuellement substitué; R?2¿ représente pyrrolidino, hexaméthylène-imino ou pipéridino.
Singh Jai P.
Wiernicki Todd R.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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