Methods for inhibition of nkt cells

Details Methods for inhibition of nkt cells Methods for inhibition of nkt cells

A - Human Necessities

61

K

A61K 31/70 (2006.01)

Patent

CA 2584971

Molecules that interact with the NKT cell antigen receptor and its counterpart antigen presenting molecule, but which inhibit the NKT cell immune function, are administered to a patient. Conditions of particular interest include the treatment of systemic lupus erythematosus (SLE), cancer, atherosclerosis, and allergic disease. In some embodiment of the invention, the inhibitory agent is an anergizing glycolipid, for example .beta.-galactosylceramide. Pharmaceutical formulations of such glycolipids are provided, and find use in the treatment of diseases involving undesirable NKT cell activation.

On administre à un patient des molécules interagissant avec le récepteur de l'antigène de la cellule NKT et avec sa contrepartie la molécule comportant ledit antigène, mais qui inhibe la fonction immunitaire de la cellule NKT. Les applications d'un intérêt particulier englobent le traitement du lupus érythémateux systémique, du cancer, de l'athérosclérose et des maladies allergiques. Dans certaines exécutions de l'invention, l'agent inhibiteur est un glycolipide anergisant, par exemple la ß-galactosylcéramide. L'invention porte également sur des préparations pharmaceutiques de ces glycolipides s'utilisant pour le traitement de maladies impliquant une activation indésirable des cellules NKT.

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