Methods for interfering with glucocorticoid induced gastric...

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G01N 33/68 (2006.01)

Patent

CA 2641325

A method for altering glucocorticoid induced gastric acid secretion comprising, contacting cells expressing serum and glucocorticoid inducible kinase (SGK) with a substance that modulates said glucocorticoid inducible kinase. Furthermore the invention relates to the diagnosis and to the identification of compounds that may be agonists, antagonists that are potentially useful in therapy of pathological gastric acid secretion.

La présente invention concerne un procédé permettant de modifier la sécrétion d'acide gastrique induite par un glucocorticoïde qui consiste à mettre en contact des cellules exprimant une kinase inductible par sérum et glucocorticoïde (SGK) avec une substance qui module cette kinase inductible par glucocorticoïde. Cette invention concerne aussi le diagnostic et l'identification de composés qui peuvent être des agonistes, des antagonistes potentiellement utiles dans une thérapie de sécrétion acide gastrique pathologique.

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