Methods for judging the possibility of the onset of bovine...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C12Q 1/70 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2261996

A method for judging the possibility of the onset of bovine leukemia caused by bovine leukemia virus (BLV) wherein an individual carrying the amino acid sequence Val-Asp-Thr-Tyr as the one specified by the amino acid numbers 75 to 78 in the .beta.1 domain of the bovine MHC Class II DR.beta. chain is judged to have a fear of the onset of this disease; and a method for judging the resistance to the onset of bovine leukemia caused by BLV wherein an individual carrying the amino acid Val as the one specified by the amino acid number 78 in the .beta.1 domain of the bovine MHC Class II DR.beta. chain is judged to be resistant thereto.

L'invention concerne un procédé permettant d'évaluer la possibilité d'apparition de la leucémie bovine induite par le virus leucémogène bovin, dans lequel un sujet porteur de la séquence d'acides aminés Val-Asp-Thr-Tyr telle que celle désignée par les numéros d'acides aminés 75 à 78 dans le domaine .beta.1 de la chaîne DR.beta. de classe II du CMH bovin est considéré comme susceptible de contracter ladite maladie. L'invention porte aussi sur une méthode d'évaluation de la résistance à ladite leucémie bovine induite par le virus leucémogène bovin, dans lequel un sujet porteur de l'acide aminé Val désigné par le numéro d'acide aminé 78 dans le domaine .beta.1 de la chaîne DR.beta. de classe II du CMH bovin est considéré comme résistant à ladite maladie.

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