Methods for labelling oligonucleotides

Details Methods for labelling oligonucleotides Methods for labelling oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07H 19/04 (2006.01)

Patent

CA 2098187

2098187 9210505 PCTABS00013 A method for labelling the 5' end of a nucleotide synthesized on a solid support involves reacting the free 5' hydroxyl with a reactant member selected to activate the 5' terminus; reacting the activated 5' terminus with a marker molecule containing a nucleophilic group; and cleaving the labelled nucleotide from the solid phase. The invention also relates to nucleotides labelled at their 5' end by the above process, wherein the nucleophilic group of the marker moiety is covalently attached directly to the 5' carbon; and to nucleotide intermediates having activated 5' termini.

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