Methods for lightening skin and hair

Details Methods for lightening skin and hair Methods for lightening skin and hair

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 6/00 (2006.01)

Patent

CA 2481784

Methods are described wherein the skin of a vertebrate, or the skin or hair of a mammal can be lightened by administration of a substance, e.g., protein, peptide, active fusion protein, active fragment, or molecular mimic, that binds to BMP-4 transmembrane receptors on melanocytes and decreases the level of melanin synthesis. Also described are methods to identify molecules that mimic the function of BMP-14 in causing a decrease in melanin in melanocytes.

La présente invention concerne des procédés par lesquels la peau d'un vertébré ou la peau ou les poils d'un mammifère peuvent être éclaircis par l'administration d'une substance, par exemple une protéine, un peptide, une protéine de fusion active, un fragment actif ou un mimétique moléculaire qui se fixe aux récepteurs transmembranaire BMP-4 sur des mélanocytes et qui abaisse le niveau de synthèse de la mélamine. Cette invention concerne aussi des techniques d'identification de molécules qui imitent la fonction de BMP-4 en entraînant une diminution de la mélamine dans des mélanocytes.

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