Methods for lowering hif-1 mediated gene expression

Details Methods for lowering hif-1 mediated gene expression Methods for lowering hif-1 mediated gene expression

A - Human Necessities

61

K

A61K 38/06 (2006.01) A61K 31/198 (2006.01) A61K 31/375 (2006.01) A61K 31/4172 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2585268

The present invention relates to the elucidation of specific molecular features of endogenous amino acids and their derivatives for inhibiting hypoxia-inducible gene expression by preventing inactivation of hypoxia- inducible factor hydroxylating enzymes. This invention encompasses agents that can be used to reduce tissue vascularization, cancer cell survival, and to treat obesity.

L'invention concerne l'élucidation de caractéristiques moléculaires spécifiques d'acides aminés endogènes et de leurs dérivés dans l'inhibition de l'expression génique inductible par l'hypoxie, par prévention de l'inactivation d'enzymes hydroxylant le facteur inductible par l'hypoxie. L'invention concerne également des agents pouvant être utilisés pour réduire la vascularisation tissulaire, la survie de cellules cancéreuses, et pour traiter l'obésité.

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