Methods for lowering platelet counts

Details Methods for lowering platelet counts Methods for lowering platelet counts

A - Human Necessities

01

N

A01N 43/12 (2006.01) A61K 31/4025 (2006.01) A61K 31/4535 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2301806

A method of safely lowering platelet count in a human which comprises the administration to a human in need thereof of an effective amount of a compound of formula (I), wherein R1 and R3 are, independently, -H, -CH3, -CO(C1- C6alkyl), or -COAr, where Ar is optionally substituted phenyl; R3 is selected from the group consisting of pyrrolidine, piperidine, and hexamethyleneimino; or a pharmaceutically acceptable salt or solvate thereof.

L'invention a pour objet un procédé permettant d'abaisser la numération plaquettaire en toute sécurité, chez l'homme. Ce procédé consiste à administrer à un patient nécessitant un tel traitement, une quantité efficace d'un composé présentant la formule (I). Dans cette dernière, R?1¿ et R?3¿ représentent indépendamment -H, -CH¿3?, -CO(alkyle C¿1?-C¿6?), ou -COAr, où Ar représente phényle éventuellement substitué; R?3¿ est sélectionné dans le groupe se composant de pyrrolidine, pipéridine, et héxaméthylèneimino; ou un sel pharmaceutiquement acceptable ou un solvate de ces derniers.

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