Methods for maintaining or restoring tissue-appropriate...

Details Methods for maintaining or restoring tissue-appropriate... Methods for maintaining or restoring tissue-appropriate...

C - Chemistry, Metallurgy

07

K

C07K 14/51 (2006.01) A61K 38/18 (2006.01) C07K 14/47 (2006.01) C12N 15/86 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2314821

Methods for maintaining or restoring tissue-appropriate phenotype of diseased, damaged, or aged mammalian soft tissue cells and methods for treating disorder characterized by a decreased level of endogenous expression of a morphogen. The methods of the invention serve to manipulate any one or several aspects of morphogen-activated regulatory pathways of phenotype-specific protein expression.

Cette invention concerne des méthodes permettant de conserver et de restaurer un phénotype approprié aux tissus dans des cellules pathologiques, lésées ou vieillies des tissus mous de mammifère ainsi que des méthodes permettant de traiter les troubles caractérisés par un niveau réduit d'expression endogène d'un morphogène. Les méthodes selon l'invention conviennent pour manipuler un ou plusieurs aspects des voies régulatrices, activées par un morphogène, de l'expression de la protéine spécifique du phénotype.

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