Methods for making proteins containing free cysteine residues

Details Methods for making proteins containing free cysteine residues Methods for making proteins containing free cysteine residues

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) A61K 47/48 (2006.01) C07K 14/475 (2006.01) C07K 14/505 (2006.01) C07K 14/555 (2006.01) C07K 14/56 (2006.01) C07K 14/61 (2006.01) C07K 14/72 (2006.01) C07K 17/08 (2006.01) C12N 15/20 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2359345

The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form pegylated proteins.

L'invention concerne des techniques qui permettent de produire des protéines solubles contenant des cystéines libres. Selon lesdites techniques, on expose une cellule hôte à un agent bloquant la cystéine, puis on modifie éventuellement les protéines solubles obtenues afin d'accroître leur efficacité. Ces modifications peuvent consister à fixer un groupe PEG afin de former des protéines pégylées.

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