Methods for making simvastatin and intermediates

Details Methods for making simvastatin and intermediates Methods for making simvastatin and intermediates

C - Chemistry, Metallurgy

12

P

C12P 17/06 (2006.01) C07D 309/30 (2006.01)

Patent

CA 2543348

The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.

L'invention concerne des procédés synthétiques chimiques et chimioenzymatiques permettant de produire de la simvastatine et de nombreux intermédiaires. Dans un mode de réalisation, des enzymes telles que des hydrolases, par exemple des estérases, sont utilisées dans les procédés de l'invention.

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