Methods for managing adipocyte fat accumulation

Details Methods for managing adipocyte fat accumulation Methods for managing adipocyte fat accumulation

A - Human Necessities

61

K

A61K 31/352 (2006.01) A61K 36/752 (2006.01) A61P 3/04 (2006.01)

Patent

CA 2620013

The present invention provides methods for management fat accumulation in an adipocyte using compositions comprising a polymethoxylated flavone fraction of at least one of 5,6,7,3',4'-pentamethoxyflavone (sinensetin); 5,6,7,8,3',4'- hexamethoxyflavone (nobiletin); 5,6,7,8,4'-pentamethoxyflavone (tangeretin); 5- hydroxy-6,7,8,3',4'-pentamethoxyflavone (auranetin); 5-hydroxy-7,5,8,3',4'- tetramethoxyflavone; 5,7-dihydroxy-6,8,3'.,4'-tetramethoxyflavone; 5,7,8,3',4'- pentamethoxyflavone; 5,7,8,4'-tetramethoxyflavone; 3,5,6,7,8,3',4'- heptamethoxyflavone; 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone; 5-hydroxy- 6,7,8,4'-tetramethoxyflavone; 5,6,7,4'-tetramethoxyflavone; 7-hydroxy- 3,5,6,8,3',4'-hexamethoxyflavone; or 7-hydroxy-3,5,6,3',4'- pentamethoxyflavone. In certain embodiments, methods for preventing rebound weight gain in a subject who has experienced weight loss are provided.

L'invention concerne des procédés visant à lutter contre l'accumulation de graisse dans un adipocyte au moyen de compositions comprenant une fraction flavone polyméthoxylée d'au moins un des composés du groupe suivant: 5,6,7,3',4'-pentaméthoxyflavone (sinensetine); 5,6,7,8,3',4'-hexaméthoxyflavone (nobiletine); 5,6,7,8,4'-pentaméthoxyflavone (tangeretine); 5-hydroxy-6,7,8,3',4'-pentaméthoxyflavone (auranetine); 5-hydroxy-7,8,3',4'-tétraméthoxyflavone; 5,7-dihydroxy-6,8,3',4'-tétraméthoxyflavone; 5,7,8,3',4'-pentaméthoxyflavone; 5,7,8,4'-tétraméthoxyflavone; 3,5,6,7,8,3',4'-heptaméthoxyflavone; 5-hydroxy-3,6,7,8,3',4'-hexaméthoxyflavone; 5-hydroxy-6,7,8,4'-tétraméthoxyflavone; 5,6,7,4'-tétraméthoxyflavone; 7-hydroxy-3,5,6,8,3',4'-hexaméthoxyflavone; ou 7-hydroxy-3,5,6,3',4'-pentaméthoxyflavone. Certains modes de réalisation concernent des méthodes permettant de prévenir une reprise de poids chez un sujet ayant perdu du poids.

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