Methods for manipulating phagocytosis mediated by cd47

Details Methods for manipulating phagocytosis mediated by cd47 Methods for manipulating phagocytosis mediated by cd47

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) C12N 5/078 (2010.01)

Patent

CA 2711938

Methods are provided to manipulate phagocytosis of cells, including hematopoietic cells, e.g. circulating hematopoi-etic cells, bone marrow cells, etc.; and solid tumor cells. In some embodiments of the invention the circulating cells are hematopoietic stem cells, or hematopoietic progenitor cells, particularly in a transplantation context, where protection from phagocytosis is desir-able. In other embodiments the circulating cells are leukemia cells, particularly acute myeloid leukemia (AML), where increased phagocytosis is desirable.

L'invention porte sur des procédés permettant de manipuler une phagocytose de cellules, comprenant des cellules hématopoïétiques, par exemple des cellules hématopoïétiques circulantes, des cellules de la moelle osseuse, entre autres ; et des cellules de tumeurs solides. Dans certains modes de réalisation de l'invention, les cellules circulantes sont des cellules souches hématopoïétiques, ou des cellules progénitrices hématopoïétiques, en particulier dans un contexte de transplantation, où la protection contre la phagocytose est souhaitable. Dans d'autres modes de réalisation, les cellules circulantes sont des cellules de leucémie, en particulier de leucémie myéloïde aiguë (AML), où une phagocytose accrue est souhaitable.

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