Methods for measuring concentrations of biomolecules

G - Physics – 01 – N

Patent

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Details

G01N 33/58 (2006.01) C12Q 1/37 (2006.01) G01N 33/48 (2006.01) G01N 33/53 (2006.01) G01N 33/60 (2006.01)

Patent

CA 2745839

The present invention provides methods for measuring the absolute concentration of a biomolecule of interest in a subject. Such biomolecules may be implicated in one or more neurological and neurodegenerative diseases or disorders. Also provided is a method for determining whether a therapeutic agent affects the in vivo metabolism of a central nervous system derived biomolecule. Also provided are kits for performing the methods of the invention.

La présente invention concerne des procédés de mesure de la concentration absolue d'une biomolécule d'intérêt chez un sujet. De telles biomolécules peuvent être impliquées dans une ou plusieurs maladies ou troubles neurologiques et neurodégénératifs. L'invention concerne également un procédé permettant de déterminer si un agent thérapeutique affecte le métabolisme in vivo d'une biomolécule dérivée du système nerveux central. Des kits permettant de mettre en oeuvre les procédés selon la présente invention sont également décrits.

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