Methods for minimizing bone loss

Details Methods for minimizing bone loss Methods for minimizing bone loss

A - Human Necessities

61

K

A61K 38/29 (2006.01) A61K 31/10 (2006.01) A61K 31/16 (2006.01) A61K 31/38 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/445 (2006.01) A61K 31/4535 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2223174

The present invention provides a method for minimizing the bone loss effect of a compound of formula (I) wherein R is -CH2CON(CH3) -n-CH2CH2CH2CH3 or - SO(CH2)3CF2CF3, or a pharmaceutically acceptable salt thereof, and wherein said formula (I) compound is administered to a mammal in need of treatment, comprising concurrently or sequentially administering to said mammal an effective amount of a compound of formula (II) wherein each R1 is independently -H, -OH,-O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), or - OSO2(C4-C6 alkyl); and R2 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1- pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; or a pharmaceutically acceptable salt thereof. Also provided is a method for minimizing bone loss induced by the administration of formula (I) compound comprising concurrently or sequentially administering a bone anabolic agent. Pharmaceutical compositions are also provided.

Procédé permettant de réduire l'effet de perte osseuse induit par un composé de formule (I) dans laquelle R est -CH¿2?CON(CH¿3?) -n-CH¿2?CH¿2?CH¿2?CH¿3? ou -SO(CH¿2?)¿3?CF¿2?CF¿3?, ou un sel pharmaceutiquement acceptable dudit composé, ledit composé de formule (I) étant administré à un mammifère nécessitant un traitement. Ledit procédé consiste à administrer parallèlement ou séquentiellement à ce mammifère une quantité efficace d'un composé de formule (II) dans laquelle chaque R?1¿ est indépendamment -H, -OH, -O(alkyle C¿1?-C¿4?), -OCOC¿6?H¿5?, -OCO(alkyle C¿1?-C¿6?) ou -OSO¿2?(alkyle C¿4?-C¿6?) et R?2¿ est 1-pipéridinyle, 1-pyrrolidinyle, méthyle-1-pyrrolidinyle, diméthyle-1-pyrrolidinyle, 4-morpholino, diméthylamino, diéthylamino ou 1-hexaméthylèneimino, ou un sel pharmaceutiquement acceptable dudit composé. Un procédé de réduction de la perte osseuse induite par l'administration d'un composé de formule (I) consistant à administrer parallèlement ou séquentiellement un agent anabolisant osseux est également décrit. Des compositions pharmaceutiques sont aussi décrites.

Affiliated with

Also associated with

Rating

Methods for minimizing bone loss does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for minimizing bone loss, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for minimizing bone loss will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1992955