C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C07H 21/00 (2006.01) C07K 1/00 (2006.01) C12N 15/09 (2006.01) C12N 15/10 (2006.01) C12N 15/66 (2006.01) C12P 19/34 (2006.01) C12P 21/02 (2006.01) C12Q 1/34 (2006.01) C40B 50/06 (2006.01) G01N 33/15 (2006.01)
Patent
CA 2094495
The invention relates to methods and mutation linkers to modify DNA, to methods for producing libraries containing a multiplicity of modified DNA, and to methods for using such libraries for screening modified proteins encoded by such DNA. The DNA targeted for modification typically encodes a polypeptide such as an enzyme. The libraries ara used to determine the effect of such modification or the interaction of the modified polypeptides with a target. In preferred embodiments, the invention relates to methods for making and using libraries containing DNA encoding modified antibiotic hydrolases to screen antibiotics against one or more of the modified antibiotic hydrolases produced by such libraries. Susceptibility or lack of susceptibility of an antibiotic to neutralizaation provides an indication of whether wild-type antibiotic hydrolases are likely to mutate to confer resistance to the antibiotic.
Botstein David
Palzkill Timothy
Genentech Inc.
Smart & Biggar
LandOfFree
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