Methods for modulating bladder function

Details Methods for modulating bladder function Methods for modulating bladder function

A - Human Necessities

61

K

A61K 31/167 (2006.01) A61K 31/24 (2006.01) A61K 31/4015 (2006.01) A61K 31/405 (2006.01) A61P 13/00 (2006.01)

Patent

CA 2450467

This invention provides methods and pharmaceutical compositions for maintaining bladder control or treating urinary incontinence in a mammal utilizing agonists of KCNQ potassium channels, including KCNQ2, KCNQ3, KCNQ4 and KCNQ5 potassium channels, alone or in combination. Compounds useful in these methods include the 1,2,4-triamino-benzene derivatives and the substituted 3-phenyl oxindole compounds. Among the preferred compounds of this invention is N-[2-amino-4-(4-fluorobenzylamino)-phenyl]carbamic acid ethyl ester, also referred to as retigabine.

L'invention concerne des méthodes et des compositions pharmaceutiques permettant de maintenir le contrôle de la vessie ou de traiter l'incontinence urinaire chez un mammifère au moyen d'agonistes des canaux potassiques KCNQ, qui comprennent des agonistes des canaux KCNQ2, KCNQ3, KCNQ4 et KCNQ5 utilisés individuellement ou de manière combinée. Les composés convenant pour ces méthodes comprennent les dérivés de 1,2,4-triamino-benzène décrits dans le brevet <= U.S. Patent No. 5,384,330 (Dieter et al.) >= et les composés 3-phényle oxindole décrits dans le brevet <= U.S. Patent No. 5,565,483 (Hewawasam et al.) >=. L'un des composés préférés est l'ester éthylique d'acide N-[2-amino-4-(4-fluorobenzylamino)-phényl]carbamique également connu sous le nom de retigabine .

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