Methods for modulating gap junctions

Details Methods for modulating gap junctions Methods for modulating gap junctions

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01) A61K 31/137 (2006.01) A61K 31/352 (2006.01) A61K 31/522 (2006.01) A61K 38/45 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2450159

A method for modulating gap junctions is provided. In a first step, the transcription of connexin is enhanced and the gap junction is relocalized at the cell membrane; in a second step, gap junction function is restored by properly gating the channel and/or inducing apoptosis. The method preferably comprises a providing a cell or an animal with a first compound for increasing the activity of protein kinase A (PKA) and in the second step providing the cell or animal with a second compound for specifically inhibiting or activating one or more protein kinase C (PKC) isoforms and/or for specifically inhibiting p38 MAP kinase.

La présente invention concerne un procédé de modulation de jonctions lacunaires. Dans une première étape, on améliore la transcription de connexine et on effectue une relocalisation de la jonction lacunaire au niveau de la membrane cellulaire ; dans une deuxième étape on restitue la jonction lacunaire par le contrôle approprié du canal et/ou l'induction d'apoptose. Le procédé comprend de préférence la fourniture à une cellule ou à un animal d'un premier composé destiné à accroître l'activité de la protéine kinase A (PKA) et dans la deuxième étape la fourniture à la cellule ou à l'animal d'un deuxième composé destiné à l'inhibition ou l'activation de la protéine kinase C (PKC) et/ou à l'inhibition spécifique de la kinase p38 associée aux microtubules.

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