A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/13 (2006.01) A61K 31/131 (2006.01) A61K 31/155 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2308274
Methods for modulating macrophage proliferation in an individual afflicted wiht or at risk for a macrophage-associated disease are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated in a number of serious disorders, including AIDS (HIV)-associated dementia, AIDS-associated non-Hodgkin's lymphoma, and Alzheimer's disease. The invention also provides methods for aiding diagnosis and monitoring therapy of a macrophage-associated non-HIV associated dementia, especially Alzheimer's disease. The invention also provides methods of delaying development of macrophage-associated non-HIV associated dementias, including Alzheimer's disease, which entail administration of an agent which modulates macrophage proliferation.
L'invention concerne des procédés pour moduler la prolifération des macrophages chez un individu souffrant d'une maladie liée aux macrophages ou présentant des risques de cette maladie. Selon les procédés de l'invention, on utilise un analogue de polyamine ou un sel ou un dérivé protégé dudit analogue. La prolifération des macrophages est liée à plusieurs troubles graves tels que la démence causée par le SIDA (par le VIH), le lymphome non hodgkinien et la maladie d'Alzheimer. L'invention concerne également des procédés destinés à faciliter le diagnostic et à surveiller la thérapie d'une démence liée aux macrophages mais non au VIH, en particulier de la maladie d'Alzheimer. De plus, l'invention concerne des procédés pour freiner les démences liées aux macrophages mais non au VIH, y compris la maladie d'Alzheimer, lesdits procédés comprenant l'administration d'un agent modulant la prolifération des macrophages.
Borden Ladner Gervais Llp
The Regents Of The University Of California
LandOfFree
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