Methods for modulating nerve cell function

Details Methods for modulating nerve cell function Methods for modulating nerve cell function

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2306776

The amount of active Robo expressed on a cell is modified by modulating the effective amount of a Comm polypeptide in contact with the cell, whereby the amount of expressed active Robo is modulated inversely with the modulation of the effective amount of the Comm polypeptide in contact with the cell. In a particular embodiment, the Comm polypeptide is provided to the cell exogenously in a pharmaceutically acceptable composition. In another aspect, the invention provides methods of screening for agents which modulate Robo- Comm interactions. These methods generally involve forming a mixture of a Robo- expressing cell, a Comm polypeptide and a candidate agent, and determining the effect of the agent on the amount of Robo expressed by the cell.

La quantité de Robo actif exprimé sur une cellule est modifiée par modulation de la quantité efficace d'un polypeptide Comm mis en contact avec ladite cellule, la quantité de Robo actif exprimé étant modulée inversement à la modulation du polypeptide Comm. Selon un mode de réalisation particulier, le polypeptide Comm est fourni à la cellule, de manière exogène, dans une composition pharmaceutiquement acceptable. Selon un autre mode de réalisation, l'invention concerne également des procédés de criblage des agents qui modulent les interactions Robo-Comm. Ces procédés impliquent généralement la formation d'un mélange d'une cellule exprimant Robo, d'un polypeptide Comm et d'un agent candidat, et la détermination de l'effet de l'agent sur la quantité de Robo exprimé par la cellule.

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