A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/711 (2006.01) A61K 35/14 (2006.01)
Patent
CA 2220012
Methods for protecting a T cell from cell death are described. The methods involve contacting the T cell with an agent which augments the bcl-X L protein level in the T cell such that it is protected from cell death. The invention further pertains to methods for increasing the susceptibility of a T cell to cell death, comprising contacting the T cell with at least one agent which decreases bcl-X L protein level in the T cell. Both in vivo and in vitro methods are described.
L'invention se rapporte à des procédés visant à éviter la mort d'un lymphocyte T. Ces procédés consistent à mettre en contact le lymphocyte T avec un agent qui augmente le taux des protéines bcl-XL dans le lymphocyte T de façon à lui éviter la mort. L'invention se rapporte également à des procédés visant à accroître la résistance d'un lymphocyte T pour lui éviter la mort, ce procédé consistant à mettre le lymphocyte T en contact avec au moins un agent qui réduit le taux des protéines bcl-XL dans le lymphocyte T. Des procédés in vivo et in vitro sont également décrits.
June Carl H.
Thompson Craig B.
Arch Development Corporation
Gowling Lafleur Henderson Llp
United States Of America Represented By The Secretary Of The Navy
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