Methods for modulating the length of telomeres by modulating...

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) A61K 31/70 (2006.01) A61K 38/08 (2006.01) A61K 38/48 (2006.01) A61K 38/55 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2251860

The present invention relates to the length of telomeres and to their effect on proliferation and senescence in cells. More precisely, it concerns the ability of hnRNP A1 and its shortened derivative UP1 to alter the length of telomeres in cells. The present invention relates more particularly to methods that modulate the proteolytic conversion of A1 into UP1 as means of decreasing or increasing the proliferative capacity of cells and to precipitate or delay the onset of senescence.

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