Methods for modulating the proliferation and differentiation...

Details Methods for modulating the proliferation and differentiation... Methods for modulating the proliferation and differentiation...

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) A61K 35/12 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C12N 15/00 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2700926

Modulators of TRIM-NHL proteins and their use for modulating the proliferation and differentiation potential of stem cells and progenitor cells. Inhibitors of TRIM-NHL proteins, e.g. TRIM32, are useful for stem cell maintenance in vitro and in vivo. Assay methods for identifying TRIM-NHL protein modulators make use of the E3 ligase activity of TRIM32 or its interaction with Argonaute-1.

L'invention porte sur des modulateurs de protéines TRIM-NHL et sur leur utilisation pour moduler le potentiel de prolifération et de différenciation de cellules souches et de cellules progénitrices. Des inhibiteurs de protéines TRIM-NHL, par exemple TRIM32, sont utiles pour l'entretien des cellules souches in vitro et in vivo. Des procédés d'essai pour identifier des modulateurs de protéines TRIM-NHL font usage de l'activité de E3 ligase de TRIM32 ou de son interaction avec l'Argonaute-1.

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