Methods for modulating the proliferation of hematopoietic cells

Details Methods for modulating the proliferation of hematopoietic cells Methods for modulating the proliferation of hematopoietic cells

C - Chemistry, Metallurgy

12

N

C12N 5/078 (2010.01) A61K 35/14 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2409448

Described are methods for proliferating or causing apoptosis of erythroid progenitor cells by contacting the cells with polypeptides having integrin VLA- 5 or VLA-4 binding sites, respectively. Cellular populations cultured under such conditions may find use in the treatment of subjects having natural or induced hematopoietic deficiencies, in the study of erythroid cell development, and in other areas.

L'invention concerne des procédés permettant la prolifération ou provoquant l'apoptose de cellules souches érythroblastes consistant à mettre en contact les cellules respectivement avec des polypeptides possédant des sites de liaison d'intégrine VLA-5 ou VLA-4. Des populations de cellules cultivées dans de telles conditions peuvent trouver une utilisation dans le traitement de sujets présentant des déficiences hématopoïétiques induite ou naturelle, dans l'étude du développement de cellules souches érythroblastes, et dans d'autres domaines.

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