Methods for monitoring amyotrophic lateral sclerosis

Details Methods for monitoring amyotrophic lateral sclerosis Methods for monitoring amyotrophic lateral sclerosis

G - Physics

01

N

G01N 33/569 (2006.01) A61K 31/13 (2006.01)

Patent

CA 2467333

The invention provides methods of monitoring amyotrophic lateral sclerosis (ALS) disease development of progression and monitoring an ALS therapy by determining the level of HLA-DR expression by CD14+ monocytes and/or the percentage of CD16+ cells in the population of CD14+ cells and/or the number of CD14+/CD16+ cells in peripheral blood of an individual with ALS. The invention is also directed to methods for decreasing the number of circulating CD14+ monocytes and/or the population of CD14+/CD16+ cells and/or the number of CD14+/CD16+ cells in an individual ALS. The invention is also directed to methods of screening for agents which decrease the population of CD14+monocytes with elevated HLA-DR expression and/or the population of CD14+/CD16+ cells and/or the number of CD14+/CD16+ cells in an individual with ALS.

L'invention concerne des méthodes destinées à surveiller la progression de la sclérose latérale amyotrophique (SLA) et à surveiller une thérapie anti-SLA par détermination du niveau d'expression HLA-DR par des monocytes CD14+ et/ou du pourcentage de cellules CD16+ dans la population de cellules CD14+ et/ou du nombre de cellules CD14+/CD16+ dans le sang périphérique d'un individu présentant une SLA. L'invention concerne également des méthodes destinées à réduire le nombre de monocytes CD14+ circulants et/ou la population de cellules CD14+/CD16+ et/ou le nombre de cellules CD14+/CD16+ chez un individu présentant une SLA. Cette invention se rapporte en outre à des méthodes de criblage d'agents permettant de réduire la population de monocytes CD14+ avec une expression HLA-DR élevée et/ou la population de cellules CD14+/CD16+ et/ou le nombre de cellules CD14+/CD16+ chez un individu présentant une SLA.

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