Methods for monitoring drug activities in vivo

Details Methods for monitoring drug activities in vivo Methods for monitoring drug activities in vivo

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2515677

Methods, systems and equipment useful for monitoring in vivo activities of CCI- 779 or other drugs. Numerous drug activity genes can be identified by the present invention. The expression profiles of these genes in peripheral blood mononuclear cells can be modulated by CCI-779 or other drugs. Therefore, these genes can be used as surrogate markers for monitoring drug activities in vivo.

La présente invention concerne des procédés, des systèmes et un équipement utilisés pour contrôler in vivo des activités de CCI-779 ou d'autres médicaments. Cette invention permet d'identifier de nombreux gènes d'activité de médicament. Les profils d'expression de ces gènes dans des cellules mononucléaires du sang périphérique peuvent être modulés par CCI-779 ou par d'autres médicaments. Ces gènes peuvent ainsi être utilisés en tant que marqueurs de substitution pour contrôler in vivo des activités de médicaments.

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