Methods for monitoring drug activities in vivo

Details Methods for monitoring drug activities in vivo Methods for monitoring drug activities in vivo

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2521210

Methods, systems and equipment useful for monitoring in vivo activities of CCI- 779 or other drugs. Numerous drug activity genes can be identified by the present invention. The expression profiles of these genes in peripheral blood mononuclear cells are modulateable by CCI-779 or other drugs. Therefore, these genes can be used as surrogate markers for detecting or monitoring drug activities in vivo.

L'invention concerne des méthodes, des systèmes et un équipement utiles pour la surveillance d'activités in vivo de CCI-779 ou d'autres médicaments. De nombreux gènes d'activités de médicaments peuvent être identifiés au moyen de la présente invention. Les profils d'expression de ces gènes dans les cellules mononucléaires du sang périphérique sont modulables par CCI-779 ou d'autres médicaments. Par conséquent, ces gènes peuvent être utilisés comme marqueurs substituts pour la détection ou la surveillance d'activités de médicaments in vivo.

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