G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/00 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) G01N 33/53 (2006.01) G01N 33/564 (2006.01)
Patent
CA 2614737
The present invention relates to methods useful to monitor central and peripheral nervous system neuron/axon destruction resulting from an increase in acute phase inflammatory enzymes. The methods have applicability to monitoring the progress of neurological diseases, including multiple sclerosis and Alzheimer's disease, as well as neuroinflammatory damage that results from sports injuries, vigorous physical activity or any form of physical abuse. The invention further relates to methods of treating multiple sclerosis or other diseases with an inflammatory component related to phospolipase A2.
L'invention concerne des méthodes permettant de contrôler la destruction des neurones/axones dans le système nerveux central et périphérique, due à une augmentation des enzymes en phase aiguë inflammatoire. Les méthodes peuvent être utilisées pour surveiller l'évolution de maladies neurologiques, y compris la sclérose en plaques et la maladie d'Alzheimer, ainsi que pour surveiller des dommages neuroinflammatoires provoqués par des blessures du sport, un activité physique intense ou toute autre forme d'exercice physique excessif. L'invention concerne également des méthodes de traitement de la sclérose en plaques ou d'autres maladies présentant une composante inflammatoire liée à la phospholipase A2.
Cunningham Timothy J.
Greenstein Jeffrey I.
Yao Lihua
Gowling Lafleur Henderson Llp
Philadelphia Health & Education Corporation D/b/a Drexel Univers
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