Methods for obtaining inhibitors of tirc7 ligand binding and...

Details Methods for obtaining inhibitors of tirc7 ligand binding and... Methods for obtaining inhibitors of tirc7 ligand binding and...

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2425583

Provided are uses of agents interfering with the interaction of TIRC7 with its ligand such as HLA-(Human Leukocyte associated Antigen) class II alpha (.alpha.) chain for the preparation of pharmaceutical compositions for the treatment of graft versus host disease, autoimmune diseases, allergic diseases, infectious diseases, sepsis, for the treatment of tumors, for the improvement of wound healing or for inducing or maintaining immune unresponsiveness in a subject. In addition, methods for identifying and obtaining such agents are described. Furthermore, methods of diagnosing an immune disease or a tumor by determining the presence or absence of TIRC7 ligand are provided.

L'invention porte sur des utilisations d'agents interférant avec l'interaction de la protéine TIRC7 avec son ligand, comme la chaîne alpha de HLA (antigène d'histocompatibilité) de classe II, dans la préparation de compositions pharmaceutiques pour le traitement des réactions de rejet du greffon contre l'hôte, de maladies auto-immunes, de maladies allergiques, de maladies infectieuses, du sepsis. Lesdits agents sont également utilisés pour traiter des tumeurs, pour améliorer la guérison de blessures ou pour induire ou maintenir chez le sujet une absence de réponse immunitaire. L'invention porte, en outre, sur des méthodes permettant d'identifier et d'obtenir ces types d'agents. Ladite invention concerne aussi des méthodes permettant de diagnostiquer une maladie immunitaire ou une tumeur en fonction de la présence ou de l'absence du ligand de la protéine TIRC7.

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