C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 2/00 (2006.01) C07K 1/00 (2006.01)
Patent
CA 2530756
The invention provides a method for reducing immunogenicity of a peptide, protein or protein complex in an individual comprising introducing at least one cross-link between two amino acids in the peptide, protein or protein complex that is stable or irreversible in vivo, wherein the at least one cross- link reduces the immunogenicity of the peptide, protein or protein complex in the individual compared to an identical peptide, protein or protein complex not so cross-linked.
L'invention porte sur un procédé de réduction de l'immunogénicité d'un peptide, d'une protéine ou d'un complexe de protéines chez un individu, consistant à introduire au moins une réticulation entre deux acides aminés dans le peptide, la protéine ou le complexe de protéines qui est stable ou irréversible in vivo, au moins une réticulation réduisant l'immunogénicité du peptide, de la protéine ou du complexe de protéines chez l'individu, en comparaison avec un peptide, une protéine ou un complexe de protéines identique qui n'a pas été réticulé.
Avatar Biotechnologies Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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