Methods for obtaining optically active epoxides and vicinal...

Details Methods for obtaining optically active epoxides and vicinal... Methods for obtaining optically active epoxides and vicinal...

C - Chemistry, Metallurgy

12

N

C12N 9/14 (2006.01) C12P 7/18 (2006.01) C12P 17/02 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2564130

The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific 2,2-disubstituted epoxide hydrolase activity. The invention also features nucleic acid molecules encoding such polypeptides, vectors containing such nucleic acid molecules, and cells containing such vectors. Also embraced by the invention are methods for obtaining optically active 2,2-disubstituted vicinal diols and optically active 2,2-disubstituted epoxides.

L'invention concerne des souches de levure et des polypeptides codés par des gènes de souches de levure possédant une activité énantiospécifique d'époxyde hydrolase 2,2-disubstitué. L'invention concerne également des molécules d'acide nucléique codant pour ces polypeptides, des vecteurs contenant les molécules d'acide nucléique et des cellules contenant lesdits vecteurs. L'invention concerne enfin des méthodes permettant d'obtenir des diols vicinaux et des époxydes optiquement actifs 2,2-disubstitués.

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