C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 489/02 (2006.01)
Patent
CA 2692426
The present invention relates to a one-pot method for N-demethylation and/or N- acylation of a tertiary N-methylated heterocycle such as morphine alkaloids or tropane alkaloids The method, exemplified by Scheme 1, comprises reacting said tertiary N-methylated heterocycle with an acylatmg agent in the presence of a Pd metal catalyst.
La présente invention porte sur un procédé récipient unique de N-déméthylation et/ou une N-acylation d'un hétérocycle N-méthylé tertiaire tel que les alcaloïdes morphiniques ou les alcaloïdes tropaniques. Le procédé (voir Schéma 1) comporte la réaction dudit hétérocycle N-méthylé tertiaire avec un agent d'acylation en présence d'un catalyseur métallique au Pd.
Carroll Robert James
Cox D. Phillip
Hudlicky Tomas
Leisch Hannes
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Brock University
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