Methods for pancreatic tissue regeneration

A - Human Necessities – 61 – K

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Details

A61K 39/395 (2006.01) C12N 5/071 (2010.01) A61K 35/39 (2006.01) A61K 38/19 (2006.01) A61P 1/18 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2751261

Disclosed are methods of expanding populations of pancreatic cells or inducing the generation of pancreatic progenitor cells in a subject or in culture using a therapeutically effective amount of a TWEAK receptor agonist. These methods may be used to treat diseases or conditions where enhancement of pancreatic progenitor cells for cell replacement therapy is desirable, including, e g, diabetes and conditions that result in loss of all or part of the pancreas

L'invention porte sur des procédés d'expansion de la population de cellules pancréatiques ou induisant la génération de cellules progénitrices pancréatiques chez un sujet ou dans une culture à l'aide d'une quantité thérapeutiquement efficace d'un agoniste du récepteur TWEAK. On peut utiliser ces procédés pour traiter des maladies ou des états où l'amélioration de cellules progénitrices pancréatiques d'une thérapie de remplacement cellulaire est désirable, comprenant, par exemple, le diabète et les états conduisant à la perte de la totalité ou d'une partie du pancréas.

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