G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2542984
The present invention provides a new method for the prediction of, or diagnosis of, auto-immune diseases, thereby alerting the subject to the presence of, or propensity to develop, an auto-immune disease so that preventative or therapeutic regiments may be initiated or changed so as to treat, modulate or prevent expansion of the CD4loCD40hi T cell population responsible for the destructive inflammation. The invention also discloses agents which modulate, treat or prevent expansion of CD4loCD40hi T cells. In one embodiment, the method is predictive of type 1 diabetes.
La présente invention concerne une nouvelle méthode de prédiction ou de diagnostic de maladies auto-immunes permettant d'alerter un sujet de la présence ou de sa propension à développer une maladie auto-immune, de telle manière que des regimes préventifs ou thérapeutiques peuvent être entrepris ou modifiés afin de traiter, moduler ou prévenir l'expansion de la population de lymphocytes T CD4?lo¿CD40?hi¿ responsable de l'inflammation destructrice. Cette invention a aussi trait à des agents qui permettent de moduler, de traiter ou de prévenir l'expansion de lymphocytes T CD4?lo¿CD40?hi¿. Dans un mode de réalisation, ladite méthode sert à pronostiquer les diabètes de type 1.
Gowan Intellectual Property
Wagner David H.
Webb-Waring Institute
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