Methods for predicting pregnancy outcome in a subject by hcg...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 5/12 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/26 (2006.01) G01N 21/64 (2006.01) G01N 33/53 (2006.01) G01N 33/531 (2006.01) G01N 33/533 (2006.01) G01N 33/535 (2006.01) G01N 33/543 (2006.01) G01N 33/60 (2006.01) G01N 33/74 (2006.01) G01N 33/76 (2006.01)

Patent

CA 2372666

The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non- trophoblast malignancy in a sample.

La présente invention concerne un procédé permettant de prévoir la conclusion d'une grossesse chez un sujet par détermination, dans un échantillon, de la quantité d'une isoforme moléculaire de HCG associée à un début de grossesse. La présente invention concerne en outre un procédé permettant de déterminer, dans un échantillon, la quantité de ladite isoforme moléculaire, associée à un début de grossesse, de la gonadotrophine chorionique humaine (HCG). La présente invention concerne également une trousse de diagnostic utilisée pour déterminer, dans un échantillon, la quantité de HCG associée à un début de grossesse. De plus, la présente invention concerne un anticorps qui se fixe spécifiquement à une isoforme moléculaire, associée à un début de grossesse, de gonadotrophine chorionique humaine. Enfin, la présente invention concerne des procédés pour détecter, dans un échantillon, une malignité trophoblastique ou non-trophoblastique.

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