Methods for predicting production of activating signals by...

Details Methods for predicting production of activating signals by... Methods for predicting production of activating signals by...

G - Physics

01

N

G01N 33/68 (2006.01) C12Q 1/68 (2006.01) G01N 33/48 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2739357

The present invention provides human binding proteins and antigen-binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL21R), and uses therefore. The invention further provides methods to predict whether the binding proteins of the invention may take on agonistic activities in vivo and produce a cytokine storm. In addition, the invention provides methods for determining whether an anti-IL21R binding protein is a neutralizing anti-IL21R binding protein, based on the identification of several IL21-responsive genes. The binding proteins can act as, e.g., antagonists of IL21R activity, thereby modulating immune responses in general, and those mediated by IL21R in particular.

La présente invention concerne la production de protéines de liaison humaines et des fragments de liaison d'antigène de celles-ci qui se lient spécifiquement au récepteur d'interleukine-21 humain (IL21R), et des utilisations de ceux-ci. L'invention concerne en outre des procédés pour prédire si les protéines de liaison de l'invention peuvent avoir des activités agonistes in vivo et produire un choc cytokinique. De plus, l'invention concerne des procédés pour déterminer si une protéine de liaison anti-IL21R est une protéine de liaison anti-IL21R neutralisante, sur la base de l'identification de plusieurs gènes répondeurs à IL21. Les protéines de liaison peuvent agir en tant que, par exemple, antagonistes de l'activité IL21R, de manière à moduler les réponses immunitaires en général, et celles véhiculées par IL21R en particulier.

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