Methods for preparation and use of psorospermin analogs

Details Methods for preparation and use of psorospermin analogs Methods for preparation and use of psorospermin analogs

C - Chemistry, Metallurgy

07

D

C07D 493/04 (2006.01) A61K 31/352 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2489768

Psorospermin is a cytotoxic dihydrofuranoxanthone that has found to exhibit significant activity against various tumor cell lines. Unfortunately, psorospermin is no longer readily available from its natural plant source. The present invention is directed to a method for preparing psorospermin analogs. Methods are also disclosed for utilizing psorospermin analogs to inhibit cellular proliferation.

La psorospermine est une dihydrofuranoxanthone cytotoxique qui fait preuve d'une activité significative contre différentes lignées de cellules tumorales. Malheureusement, la psorospermine ne peut plus être obtenue facilement à partir de sa source végétale naturelle. La présente invention concerne un procédé de préparation de psorospermine et d'analogues de psorospermine. L'invention concerne également des procédés d'utilisation d'analogues de psorospermine pour inhiber la prolifération cellulaire.

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