A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/51 (2006.01) A61K 9/12 (2006.01) A61K 9/14 (2006.01) A61K 9/50 (2006.01) A61K 9/72 (2006.01) A61K 31/496 (2006.01) A61K 31/573 (2006.01) A61P 11/00 (2006.01) C23C 14/12 (2006.01) C23C 14/28 (2006.01)
Patent
CA 2350894
Disclosed are methods using pulsed laser ablation to prepare coated drug particles of uniform size and thickness. The coated drug particles ranged in size from several nanometers to several millimeters in diameter size, and were coated with organic polymer particle having average diameter sizes from about 1 to 50 nm. In illustrative embodiments, coated drug particles or drug delivery particles are disclosed comprising a biodegradable or biocompatible polymer coating having controlled thickness and controlled coating uniformity, that offer superior pharmaceutical properties for controlled delivery and increased bioavailability.
La présente invention concerne des procédés de préparation de particules de médicaments enrobées, de taille et d'épaisseur uniforme, qui font appel à la technique de l'ablation par laser pulsé. Ces particules présentent un diamètre allant de plusieurs nanomètres à plusieurs millimètres et sont enrobées d'un polymère organique d'un diamètre moyen compris entre 1 et 50 nm environ. Selon des modes de réalisation type, les particules de médicament enrobées ou les particules d'administration de médicaments comprennent un revêtement polymère biodégradable ou biocompatible d'une épaisseur et d'une uniformité précises qui possèdent des propriétés pharmaceutiques supérieures en termes d'administration maîtrisée et de biodisponibilité accrue.
Fitz-Gerald James M.
Hochhaus Guenther
Singh Rajiv K.
Talton James D.
Riches Mckenzie & Herbert Llp
University Of Florida
University Of Florida Research Foundation Incorporated
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