Methods for preparing de-n-acylated and n-acylated...

Details Methods for preparing de-n-acylated and n-acylated... Methods for preparing de-n-acylated and n-acylated...

C - Chemistry, Metallurgy

07

H

260/230.58

C07H 15/10 (2006.01)

Patent

CA 1333903

A method for preparing de-N-acylated forms of an N-acyl sugar-containing glycospingolipid comprising hydrolyzing the glycospingolipids under mild alkaline conditions such that the N-acyl group of the sugar moiety is preferentially hydrolyzed. A method for preparing N-acylated forms of an amino sugar-containing lyso form glycospingolipid comprising protecting the amino group of the spingosine by incorporating the glycospingolipid into a phospholipid or hydrophobic matrix and then conducting selective N-acylation on the amino group of the sugar moiety. Methods for preparing labeled glycospingolipids also disclosed.

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