Methods for preparing factor x, activated factor x,...

Details Methods for preparing factor x, activated factor x,... Methods for preparing factor x, activated factor x,...

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 38/48 (2006.01)

Patent

CA 2687604

Methods for preparing Factor X, activated Factor X, inactivated factor X and inactivated factor Xa, compositions comprising Factor X and Factor Xa, inactivated Factor X and inactivated Factor Xa and methods of medical treatment using Factor X, Factor Xa, activated Factor X and inactivated Factor Xa are disclosed. The preparation methods comprise a chromatography step using an immobilised metal ion affinity chromatography substrate.

La présente invention concerne des procédés de préparation de facteur X, de facteur X activé, facteur X inactivé et facteur Xa inactivé, des compositions comportant un facteur Xa, un facteur X inactivé et un facteur Xa inactivé ainsi que des procédés de traitement médical mettant en AEuvre un facteur X, un facteur Xa, un facteur X inactivé et un facteur XA inactivé. Les procédés de préparation comprennent une étape de chromatographie à l'aide d'un substrat de chromatographie d'affinité pour ions métalliques immobilisés.

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