C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/22 (2006.01)
Patent
CA 2567922
Methods for manufacturing 7-ethyl-10-[4-(1-pipendino)-1-piperidino]- carbonyloxy- camptothecin are described comprising reacting a mixture of 1-chlorocarbonyl-4-piperidinopiperidine hydrochloride and 7-ethyl-10- hydroxycamptothecin in a polar aprotic solvent with a base in the presence of catalytic amounts of a N-containing cyclic organic compound having 3 to 20 carbon atoms and optionally in the presence of a water binding agent in an amount which effectively binds any water present in the above reactants and solvents, or reacting A 7-Ethyl-10-hydroxycamptothecin in a polar aprotic solvent with phosgene, trichlormethyl- chloroformate, bis(trichloromethyl)carbonate or a alternative to phosgene and a base in the presence of catalytic amounts of a N-containing cyclic organic compound having 3 to 20 carbon atoms and subsequently B with piperidinopiperidine and an amine base
Rauter Holger
Werner Silvia
Wissmann Friedrich
Macrae & Co.
W.c. Heraeus Gmbh
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