Methods for preparing polymeric buffer formulations for...

A - Human Necessities – 61 – N

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A61N 1/30 (2006.01)

Patent

CA 2546399

The present invention provides methods for preparing compositions for use in electrotransport delivery systems that comprise providing a drug solution comprising drug ions and associated counterions; adjusting the pH of the drug solution by contacting the drug solution with a first ion exchange material; separating the first ion exchange material from the pH-adjusted drug solution; adding the pH-adjusted drug solution to a reservoir of an electrotransport delivery system; and contacting the pH-adjusted drug solution with a second ion exchange material.

La présente invention concerne des procédés de préparation de compositions destinées à être utilisées dans des systèmes d'apport par électrotransport qui consistent à employer une solution de médicament comprenant des ions de médicament et des contre-ions associés; à ajuster le pH de la solution de médicament par mise en contact de la solution de médicament avec une première matière échangeuse d'ions; à séparer la première matière échangeuse d'ions de la solution de médicament à pH ajusté; à ajouter la solution de médicament à pH ajusté à un réservoir d'un système d'apport par électrotransport; et à mettre en contact la solution de médicament à pH ajusté avec une deuxième matière échangeuse d'ions.

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