Methods for preparing purified lipopeptides

Details Methods for preparing purified lipopeptides Methods for preparing purified lipopeptides

C - Chemistry, Metallurgy

07

K

C07K 7/64 (2006.01) C07K 7/08 (2006.01) C07K 14/36 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2432096

The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.

L'invention porte sur des formes cristallines et de type cristal de lipopeptides, comprenant une daptomycine, un antibiotique lipopeptidique à activité bactéricide puissante contre la bactérie gram-positif, contenant des souches résistantes aux antibiotiques conventionnels. L'invention concerne en outre des procédés de purification des lipopeptides, comprenant une daptomycine, un antibiotique lipopeptidique à activité bactéricide puissante contre la bactérie gram-positif, contenant des souches résistantes aux antibiotiques conventionnels. L'invention concerne également des compositions pharmaceutiques comprenant la forme purifiée du lipopeptide et les procédés d'application de ces compositions.

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