Methods for preventing adsorption of thrombopoietin (tpo)...

A - Human Necessities – 61 – K

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A61K 38/19 (2006.01) A61K 47/02 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01) A61K 47/32 (2006.01) A61K 47/38 (2006.01) A61K 47/42 (2006.01) A61K 47/44 (2006.01)

Patent

CA 2215315

A TPO-containing composition comprising a TPO protein having a sugar-chain moiety and at least one pharmaceutically acceptable additive selected from the group consisting of proteins, cellulose derivatives, surface active agents and polyvinyl alcohol; and a method of preventing TPO from being adsorbed on a container wall by using the above composition containing such additives, thereby preventing the titer-reduction caused by the adsorption.

Une composition contenant une thrombopoïétine (TPO) constituée d'une protéine TPO possédant une fraction constituée d'une chaîne glucidique et au moins un adjuvant pharmaceutiquement acceptable choisi parmi le groupe constitué de protéines, de dérivés de la cellulose, d'agents tensio-actifs et d'alcool polyvinylique; et une méthode pour empêcher la TPO d'être adsorbée sur la paroi d'un contenant par le recours à la composition ci-dessus contenant ces adjuvants, ce qui empêche une réduction du titre causée par l'adsorption.

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