Methods for preventing adsorption of thrombopoietin (tpo)...

A - Human Necessities – 61 – K

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A61K 38/19 (2006.01) A61K 47/06 (2006.01) A61K 47/26 (2006.01) A61K 47/30 (2006.01) A61K 47/42 (2006.01) A61K 47/44 (2006.01) A61K 47/10 (2006.01) A61K 47/18 (2006.01) A61K 47/20 (2006.01) A61K 47/32 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2215249

A TPO-containing composition comprising a TPO protein having no sugar-chain portion and at least one pharmaceutically acceptable additive selected from the group consisting of proteins, cellulose derivatives, sulfated polysaccharides, surfactants, polyvinyl alcohol, macrogols and aminoacetic acid; and a method of preventing TPO from being adsorbed on a container wall by using the above composition containing such additives, thereby preventing the titer reduction caused by the adsorption.

La présente invention concerne une composition contenant de la thrombopoïétine (TPO) comprenant une protéine de TPO sans partie de chaîne de sucre et au moins un additif acceptable sur le plan pharmaceutique, choisi dans le groupe composé de protéines, de dérivés de cellulose, de polysaccharides sulfatés, d'agents tensioactifs, d'alcool polyvinylique, de macrogols et d'acide aminoacétique; elle concerne aussi un procédé pour empêcher l'adsorption de TPO sur une paroi d'un récipient grâce à l'utilisation de la composition sus-mentionneée qui contient de tels additifs, ce qui permet d'éviter aussi une réduction du titre, induite par l'adsorption.

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