A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/765 (2006.01) A61P 17/16 (2006.01)
Patent
CA 2756316
The present invention provides methods of protecting irradiated eukaryotic cells such as irradiated mammalian epithelial cells, from the deleterious effect of microbial pathogens such as Pseudomonas aeruginosa. The invention also provides methods of protecting irradiated organisms from such deleterious effects, resulting in reduced mortality and morbidity. Further provided are kits containing relatively high molecular weight biocompatible polymers such as polyethylene glycol, optionally supplemented with a protective polymer such as dextran and/or essential pathogen nutrients such as L-glutamine, along with instructions for administration to organisms to be exposed to radiation.
Cette invention concerne des méthodes de protection des cellules eucaryotes irradiées telles que les cellules épithéliales du mammifère, de l'effet délétère des pathogènes microbiens comme Pseudomonas aeruginosa. L'invention concerne également des méthodes de protection d'organismes irradiés de ces effets délétères, ce qui entraîne une réduction de la mortalité et de la morbidité. L'invention concerne par ailleurs des kits contenant des polymères biocompatibles de poids moléculaire relativement élevé comme le polyéthylèneglycol, éventuellement associés à un polymère protecteur comme le dextrane et/ou des nutriments essentiels pour contrer le pathogène comme la L-glutamine, ainsi que des instructions concernant l'administration de ces composés à l'organisme exposé à l'irradiation.
Alverdy John C.
Zaborina Olga
Smart & Biggar
The University Of Chicago
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