Methods for preventing and treating tissue damage associated...

Details Methods for preventing and treating tissue damage associated... Methods for preventing and treating tissue damage associated...

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2515453

A method for preventing or treating tissue damage associated with ischemia- reperfusion injury and thoraco-abdominal aortic aneurysm (TAAA) repair by administering a tissue damage preventing or treating amount of a complement inhibitor to a patient likely to suffer from or suffering from tissue damage associated with ischemia-reperfusion injury or TAAA repair. The complement inhibitors are preferably antibodies that bind to and inhibit complement proteins involved in the formation of the membrane attach complex, preferably antibodies that inhibit MBL, MASP1, MASP2, and MASP3 in the lectin pathway. The complement inhibitors can be used alone or in combination to decrease the morbidity and mortality caused by tissue damage associated with ischemia- reperfusion injury or TAAA repair.

Procédé de prévention ou de traitement des lésions tissulaires associées aux blessures dues à la reperfusion ischémique et à la réfection de l'anévrisme de l'aorte thoracique et abdominale (TAAA) par administration à un sujet atteint ou susceptible d'être atteint de lésions ou de blessures du type précité, d'une quantité d'inhibiteur de complément suffisante pour assurer la prévention ou le traitement de lésions tissulaires. Les inhibiteurs de complément sont de préférence des anticorps qui se lient à des protéines de complément impliquées dans la formation du complexe d'attaque membranaire, et préférentiellement des anticorps qui inhibent MBL, MASP1, MASP2 et MASP3 dans la voie lectinique. Les inhibiteurs de complément peuvent être utilisés seuls ou en combinaison afin de réduire la morbidité et la mortalité entraînées par les lésions tissulaires associées aux blessures dues à la reperfusion ischémique et à la réfection du TAAA.

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